ALDACTONE 100MG (SPIRONOLACTONE) IS A POTASSIUM-SPARING DIURETIC PRIMARILY USED TO TREAT:

ALDACTONE 100mg (spironolactone) is a potassium-sparing diuretic primarily used to treat:

ALDACTONE 100mg (spironolactone) is a potassium-sparing diuretic primarily used to treat:

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ALDACTONE 100mg (spironolactone) is a potassium-sparing diuretic primarily used to treat:



1. Key Uses:




  • Hypertension (High Blood Pressure): Often combined with other diuretics to reduce fluid retention.




  • Edema (Fluid Retention): Caused by heart failure, liver cirrhosis, or kidney disease.




  • Primary Hyperaldosteronism: A condition where the adrenal glands produce too much aldosterone.




  • Heart Failure: Especially in cases of reduced ejection fraction (used alongside other therapies).




  • Hirsutism/Acne (Off-label): In polycystic ovary syndrome (PCOS) due to its anti-androgenic effects.




2. Mechanism of Action:




  • Blocks aldosterone receptors → Promotes sodium/water excretion while retaining potassium.




3. Dosage:




  • Adults: Typically 25–400mg daily, depending on the condition.





    • Hypertension/Edema: Start with 25–100mg/day (may be divided).




    • Heart Failure/Hyperaldosteronism: May require higher doses (up to 400mg).






  • Take with food to improve absorption.




4. Side Effects:




  • Hyperkalemia (high potassium) – Monitor potassium levels.




  • Hormonal effects (due to anti-androgen activity):





    • Men: Gynecomastia, impotence.




    • Women: Menstrual irregularities, breast tenderness.






  • GI upset, dizziness, fatigue, dehydration.




5. Important Warnings:




  • Avoid in severe kidney disease or high potassium levels.




  • Do not use with potassium supplements/salt substitutes unless directed.




  • Contraindicated with eplerenone or certain other potassium-sparing agents.




6. Drug Interactions:




  • ACE inhibitors (e.g., lisinopril), ARBs (e.g., losartan), NSAIDs (e.g., ibuprofen): ↑ Risk of hyperkalemia.




  • Digoxin: Spironolactone may increase digoxin levels.




  • Lithium: May ↑ lithium toxicity.




7. Monitoring:




  • Serum potassium, sodium, and kidney function (especially when starting or adjusting dose).




Would you like specific advice on its use for a particular condition?

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