ALDACTONE 100mg (spironolactone) is a potassium-sparing diuretic primarily used to treat:
ALDACTONE 100mg (spironolactone) is a potassium-sparing diuretic primarily used to treat:
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ALDACTONE 100mg (spironolactone) is a potassium-sparing diuretic primarily used to treat:
1. Key Uses:
Hypertension (High Blood Pressure): Often combined with other diuretics to reduce fluid retention.
Edema (Fluid Retention): Caused by heart failure, liver cirrhosis, or kidney disease.
Primary Hyperaldosteronism: A condition where the adrenal glands produce too much aldosterone.
Heart Failure: Especially in cases of reduced ejection fraction (used alongside other therapies).
Hirsutism/Acne (Off-label): In polycystic ovary syndrome (PCOS) due to its anti-androgenic effects.
2. Mechanism of Action:
Blocks aldosterone receptors → Promotes sodium/water excretion while retaining potassium.
3. Dosage:
Adults: Typically 25–400mg daily, depending on the condition.
Hypertension/Edema: Start with 25–100mg/day (may be divided).
Heart Failure/Hyperaldosteronism: May require higher doses (up to 400mg).
Take with food to improve absorption.
4. Side Effects:
Hyperkalemia (high potassium) – Monitor potassium levels.
Hormonal effects (due to anti-androgen activity):
Men: Gynecomastia, impotence.
Women: Menstrual irregularities, breast tenderness.
GI upset, dizziness, fatigue, dehydration.
5. Important Warnings:
Avoid in severe kidney disease or high potassium levels.
Do not use with potassium supplements/salt substitutes unless directed.
Contraindicated with eplerenone or certain other potassium-sparing agents.
6. Drug Interactions:
ACE inhibitors (e.g., lisinopril), ARBs (e.g., losartan), NSAIDs (e.g., ibuprofen): ↑ Risk of hyperkalemia.
Digoxin: Spironolactone may increase digoxin levels.
Lithium: May ↑ lithium toxicity.
7. Monitoring:
Serum potassium, sodium, and kidney function (especially when starting or adjusting dose).
Would you like specific advice on its use for a particular condition?
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